Abstract
Adriamycin (Adr)-induced cardiotoxicity occurs most likely via an oxidative mechanism of action. Moderation of this activity may result in an improved therapeutic index for this compound. PZ-51, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one, is a selenoorganic compound with thiol-dependent, peroxidase-like activity. We tested this compound alone and in combination with N-acetylcysteine (NAC) for its effect on Adr-induced in vivo toxicity in Balb/c mice. These studies demonstrated that PZ-51 protects against Adr-induced lipid peroxidation in heart and liver tissue and Adr-induced toxicity in general, as measured by total serum creatine kinase activity and body weight.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylcysteine / pharmacology
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Animals
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Antioxidants / pharmacology*
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Azoles / pharmacology*
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Body Weight / drug effects
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Chemical and Drug Induced Liver Injury*
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Creatine Kinase / blood
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Doxorubicin / antagonists & inhibitors
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Doxorubicin / toxicity*
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Drug Interactions
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Female
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Heart Diseases / chemically induced*
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Heart Diseases / prevention & control
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Isoindoles
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Lipid Peroxidation / drug effects*
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Liver Diseases / prevention & control
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Mice
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Mice, Inbred BALB C
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Organoselenium Compounds / pharmacology*
Substances
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Antioxidants
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Azoles
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Isoindoles
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Organoselenium Compounds
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ebselen
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Doxorubicin
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Creatine Kinase
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Acetylcysteine