Abstract
Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetamides / adverse effects*
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Acidosis, Lactic / genetics
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Acidosis, Lactic / metabolism*
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Aged
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Anti-Bacterial Agents / adverse effects
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Female
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Genetic Predisposition to Disease
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Humans
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Linezolid
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Middle Aged
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Oxazolidinones / adverse effects*
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Polymorphism, Genetic
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Protein Biosynthesis / drug effects*
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Linezolid