Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

Markus H Kuehn; John H Fingert; Young H Kwon

doi:10.1016/j.ohc.2005.04.002

Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

Ophthalmol Clin North Am. 2005 Sep;18(3):383-95, vi. doi: 10.1016/j.ohc.2005.04.002.

Authors

Markus H Kuehn¹, John H Fingert, Young H Kwon

Affiliation

¹ Department of Ophthalmology and Visual Sciences, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242, USA.

PMID: 16054996
DOI: 10.1016/j.ohc.2005.04.002

Abstract

Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis*
Glaucoma / etiology*
Glaucoma / prevention & control
Humans
Neuroprotective Agents / therapeutic use*
Retinal Ganglion Cells / pathology*

Substances

Neuroprotective Agents