Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals

Aiko Ebisawa; Masahiro Hiratsuka; Kanako Sakuyama; Yumiko Konno; Takamitsu Sasaki; Michinao Mizugaki

doi:10.2133/dmpk.20.294

Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals

Drug Metab Pharmacokinet. 2005 Aug;20(4):294-9. doi: 10.2133/dmpk.20.294.

Authors

Aiko Ebisawa¹, Masahiro Hiratsuka, Kanako Sakuyama, Yumiko Konno, Takamitsu Sasaki, Michinao Mizugaki

Affiliation

¹ Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University, Sendai, Japan.

PMID: 16141609
DOI: 10.2133/dmpk.20.294

Abstract

We analyzed all the exons and exon-intron junctions of the CYP2D6 gene from 286 Japanese individuals. We detected two novel single nucleotide polymorphisms (SNPs) 2556C>T in exon 5 (Thr261Ile) and 3835A>C in exon 8 (Lys404Gln). Both these SNPs showed a frequency of 0.002.

Publication types

Comparative Study

MeSH terms

Asian People
Cytochrome P-450 CYP2D6 / blood
Cytochrome P-450 CYP2D6 / genetics*
DNA / chemistry
DNA / isolation & purification
Gene Frequency
Genotype
Humans
Japan
Polymorphism, Single Nucleotide*
Sequence Analysis, DNA

Substances

DNA
Cytochrome P-450 CYP2D6