Abstract
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cation Transport Proteins / chemistry
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Cation Transport Proteins / physiology*
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Humans
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Hydrogen-Ion Concentration
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Membrane Proteins / chemistry
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Membrane Proteins / physiology*
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Mice
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Neoplasm Invasiveness
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Neoplasm Metastasis*
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Neoplasms / metabolism*
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Neoplasms / pathology
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Signal Transduction
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Sodium-Hydrogen Exchanger 1
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Sodium-Hydrogen Exchangers / chemistry
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Sodium-Hydrogen Exchangers / physiology*
Substances
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Cation Transport Proteins
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Membrane Proteins
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SLC9A1 protein, human
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Slc9a1 protein, mouse
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Sodium-Hydrogen Exchanger 1
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Sodium-Hydrogen Exchangers