Abstract
MRPs are membrane proteins transporting organic anions at the expense of ATP hydrolysis. MRP2 is known to be a major transporter of organic anions from the liver into bile. We discuss recent results showing allosteric control of human but not rat MRP2. MRP3 has been considered a major player in bile salt metabolism, but our recent results with Mrp3 KO mice do not support this. Instead, we have found a role for MRP3 in the cellular export of drug-glucuronide conjugates. We discuss problems in extrapolating results obtained for murine MRPs.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bile Acids and Salts / metabolism*
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Biological Transport
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Glucuronides / metabolism*
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Humans
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Liver Diseases / metabolism*
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Liver Diseases / pathology
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Membrane Transport Proteins / physiology*
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Multidrug Resistance-Associated Protein 2
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Multidrug Resistance-Associated Proteins / physiology*
Substances
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ABCC2 protein, human
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Bile Acids and Salts
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Glucuronides
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Membrane Transport Proteins
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Multidrug Resistance-Associated Protein 2
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Multidrug Resistance-Associated Proteins
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multidrug resistance-associated protein 3