Abstract
Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology*
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Cell Adhesion / drug effects
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Corydalis / chemistry*
-
Dose-Response Relationship, Drug
-
Drug Screening Assays, Antitumor
-
Humans
-
Isoquinolines / isolation & purification
-
Isoquinolines / pharmacology*
-
Molecular Structure
-
Neutrophils / cytology
-
Plant Components, Aerial / chemistry
-
Structure-Activity Relationship
Substances
-
Alkaloids
-
Antineoplastic Agents, Phytogenic
-
Isoquinolines