Regulation of drug transporters during infection and inflammation

Mol Interv. 2007 Apr;7(2):99-111. doi: 10.1124/mi.7.2.10.

Abstract

Inflammation-induced changes in the pharmacokinetics and dynamics of numerous drugs have been reported. Altered drug disposition during inflammatory disease has traditionally been ascribed primarily to changes in drug metabolism and protein binding. Emerging evidence within the last decade, however, has demonstrated that the inflammatory response affects the expression of several important drug transporters and these changes significantly impact the disposition and activity of drug substrates.

Publication types

  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism*
  • Acute-Phase Reaction
  • Animals
  • Brain / metabolism
  • Cation Transport Proteins / metabolism*
  • Female
  • Humans
  • Infections / drug therapy
  • Infections / metabolism*
  • Inflammation / drug therapy
  • Inflammation / metabolism*
  • Intestinal Mucosa / metabolism
  • Kidney / metabolism
  • Liver / metabolism
  • Models, Biological
  • Placenta / metabolism
  • Pregnancy
  • Receptors, Cytoplasmic and Nuclear / metabolism

Substances

  • ATP-Binding Cassette Transporters
  • Cation Transport Proteins
  • Receptors, Cytoplasmic and Nuclear