Abstract
Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has been shown to be important in controlling numerous metabolic pathways; these include roles in maintaining bile acid, lipid and glucose homeostasis, in preventing intestinal bacterial infection and gallstone formation and in modulating liver regeneration and tumorigenesis. The accumulating data suggest that FXR may be a pharmaceutical target for the treatment of certain metabolic diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Bacteria / growth & development
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Bile Acids and Salts / metabolism
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DNA-Binding Proteins / metabolism*
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DNA-Binding Proteins / physiology
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Glucose / metabolism
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Humans
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Lipid Metabolism
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Liver Neoplasms / physiopathology
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Liver Regeneration
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Metabolic Diseases / metabolism*
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Receptors, Cytoplasmic and Nuclear / physiology
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Signal Transduction*
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Transcription Factors / metabolism*
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Transcription Factors / physiology
Substances
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Bile Acids and Salts
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DNA-Binding Proteins
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors
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farnesoid X-activated receptor
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Glucose