Selective 3-hydroxylation deficiency of lidocaine and its metabolite in Dark Agouti rats

Biochem Pharmacol. 1991 Jul 15;42(3):693-5. doi: 10.1016/0006-2952(91)90333-z.

Abstract

Selective and marked 3-hydroxylase deficiency of lidocaine and its N-deethylated metabolite, MEGX, were observed in male and female DA rats. These findings suggest that cytochrome P450 isozymes metabolizing debrisoquine may be involved in the 3-hydroxylations of lidocaine and MEGX in rats and humans.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 Enzyme System / metabolism*
  • Disease Models, Animal
  • Female
  • Hydroxylation
  • Lidocaine / analogs & derivatives
  • Lidocaine / metabolism*
  • Male
  • Microsomes, Liver / metabolism*
  • Mixed Function Oxygenases / metabolism*
  • Rats
  • Rats, Inbred Strains

Substances

  • Cytochrome P-450 Enzyme System
  • Lidocaine
  • monoethylglycinexylidide
  • Mixed Function Oxygenases
  • Cytochrome P-450 CYP2D6