Abstract
Selective and marked 3-hydroxylase deficiency of lidocaine and its N-deethylated metabolite, MEGX, were observed in male and female DA rats. These findings suggest that cytochrome P450 isozymes metabolizing debrisoquine may be involved in the 3-hydroxylations of lidocaine and MEGX in rats and humans.
MeSH terms
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Animals
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Cytochrome P-450 CYP2D6
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Cytochrome P-450 Enzyme System / metabolism*
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Disease Models, Animal
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Female
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Hydroxylation
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Lidocaine / analogs & derivatives
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Lidocaine / metabolism*
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Male
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Microsomes, Liver / metabolism*
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Mixed Function Oxygenases / metabolism*
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Rats
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Rats, Inbred Strains
Substances
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Cytochrome P-450 Enzyme System
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Lidocaine
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monoethylglycinexylidide
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Mixed Function Oxygenases
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Cytochrome P-450 CYP2D6