Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/debrisoquine type

Biochem Pharmacol. 1991 Jul 25;42(4):947-9. doi: 10.1016/0006-2952(91)90057-c.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Debrisoquin / metabolism*
  • Kinetics
  • Male
  • Metoprolol / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Mice, Inbred NZB
  • Mice, Inbred Strains / genetics
  • Mice, Inbred Strains / metabolism*
  • Microsomes, Liver / metabolism
  • Models, Biological
  • Oxidation-Reduction
  • Phenotype
  • Polymorphism, Genetic / physiology*
  • Sparteine / metabolism*

Substances

  • Sparteine
  • Metoprolol
  • Debrisoquin