Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

Ann N Y Acad Sci. 2011 Jul:1229:29-37. doi: 10.1111/j.1749-6632.2011.06100.x.

Abstract

The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bile Acids and Salts / metabolism
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / metabolism*
  • Cell Cycle
  • Gene Expression Regulation
  • Growth Hormone / genetics
  • Growth Hormone / metabolism*
  • Human Growth Hormone / genetics
  • Human Growth Hormone / metabolism
  • Humans
  • Lipid Metabolism
  • Liver / metabolism*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / metabolism*
  • STAT5 Transcription Factor / metabolism*
  • Signal Transduction

Substances

  • Bile Acids and Salts
  • STAT5 Transcription Factor
  • Human Growth Hormone
  • Growth Hormone