Abstract
Triptolide, a diterpenoid epoxide, is one of the major active ingredients of Tripterygium wilfordii Hook F, a woody vine plant called lei gong teng in China, which is used in traditional Chinese Medicine (TCM) for treating many diseases. In this paper, we investigate the relation between inhibition of mitochondrial respiratory chain and liver injury induced by triptolide. Results indicate that the secondary β-oxidation impairment caused by inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury, which featured by microvesicular steatosis, hyperlactacidemia and enhanced oxidant stress, although other mechanisms of triptolide-induced liver injury may also exist.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Respiration / drug effects*
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Chemical and Drug Induced Liver Injury / blood
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Chemical and Drug Induced Liver Injury / metabolism*
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Diterpenes / adverse effects*
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Epoxy Compounds / adverse effects
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Fatty Liver / chemically induced
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Female
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Lactic Acid / blood
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Liver / drug effects*
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Liver / metabolism
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Mitochondrial Membranes / drug effects*
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Mitochondrial Membranes / metabolism
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Oxidation-Reduction
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Oxidative Stress / drug effects
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Phenanthrenes / adverse effects*
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Plant Extracts / adverse effects*
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Plant Extracts / chemistry
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Rats
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Rats, Sprague-Dawley
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Tripterygium / adverse effects*
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Tripterygium / chemistry
Substances
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Diterpenes
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Epoxy Compounds
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Phenanthrenes
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Plant Extracts
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lei gong teng
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triptolide
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Lactic Acid