Adverse interactions encountered when using trazodone to treat insomnia associated with fluoxetine

Int Clin Psychopharmacol. 1990 Jul;5(3):191-4. doi: 10.1097/00004850-199007000-00004.

Abstract

The authors report adverse interactions encountered when using low dose (25-75 mg) trazodone to treat insomnia associated with fluoxetine. Sixteen patients had good hypnotic responses to trazodone, but five needed to stop the medication due to excessive sedation. Three cases are described.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Depression / drug therapy
  • Drug Interactions
  • Female
  • Fluoxetine / adverse effects*
  • Fluoxetine / therapeutic use
  • Humans
  • Sleep Initiation and Maintenance Disorders / chemically induced
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Trazodone / adverse effects*
  • Trazodone / therapeutic use

Substances

  • Fluoxetine
  • Trazodone