Abstract
Experimental studies on the molecular regulation of human drug metabolism have revealed that vitamin D up-regulates transcription of several key enzymes, such as CYP3A4, through the vitamin D receptor pathway in intestinal and hepatic cells. Recent data suggest that this results in seasonal changes with higher clearance of orally administered drugs during periods with high UV-B radiation and vitamin D levels. Taken together, vitamin D status might contribute to inter- and intraindividual differences in drug metabolism, but the therapeutic impact of these findings remains to be established.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Caco-2 Cells
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Cyclosporine / pharmacokinetics
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Cytochrome P-450 CYP3A / genetics
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Cytochrome P-450 CYP3A / metabolism
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Half-Life
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Humans
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Inactivation, Metabolic
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Pharmaceutical Preparations / metabolism
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Receptors, Calcitriol / genetics
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Receptors, Calcitriol / metabolism
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Sirolimus / pharmacokinetics
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Tacrolimus / pharmacokinetics
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Ultraviolet Rays
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Vitamin D / blood
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Vitamin D / metabolism*
Substances
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Pharmaceutical Preparations
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Receptors, Calcitriol
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Vitamin D
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Cyclosporine
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Cytochrome P-450 CYP3A
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CYP3A4 protein, human
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Sirolimus
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Tacrolimus