Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification

Clin Pharmacol Ther. 2012 Nov;92(5):559-62. doi: 10.1038/clpt.2012.143. Epub 2012 Sep 26.

Authors

D Iusuf¹, E van de Steeg, A H Schinkel

Affiliation

¹ Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

PMID: 23010652
DOI: 10.1038/clpt.2012.143

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anions
Biological Transport
Cations
Drug-Related Side Effects and Adverse Reactions
Hepatocytes / metabolism*
Humans
Hydrophobic and Hydrophilic Interactions
Liver / metabolism
Liver / pathology
Liver-Specific Organic Anion Transporter 1
Organic Anion Transporters / metabolism*
Organic Anion Transporters, Sodium-Independent / metabolism*
Pharmaceutical Preparations / chemistry
Pharmaceutical Preparations / metabolism*
Solute Carrier Organic Anion Transporter Family Member 1B3

Substances

Anions
Cations
Liver-Specific Organic Anion Transporter 1
Organic Anion Transporters
Organic Anion Transporters, Sodium-Independent
Pharmaceutical Preparations
SLCO1B1 protein, human
SLCO1B3 protein, human
Solute Carrier Organic Anion Transporter Family Member 1B3