The cellular pharmacology of methotrexate

Pharmacol Ther. 1985;28(1):77-102. doi: 10.1016/0163-7258(85)90083-x.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anions
  • Binding, Competitive
  • Biological Transport, Active / drug effects
  • Carrier Proteins / metabolism
  • Cell Line
  • Cell Membrane / metabolism*
  • Computers
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Drug Resistance
  • Folic Acid Antagonists
  • Humans
  • In Vitro Techniques
  • Leucovorin / pharmacology
  • Membrane Proteins / metabolism
  • Methotrexate / analogs & derivatives
  • Methotrexate / antagonists & inhibitors
  • Methotrexate / metabolism
  • Methotrexate / pharmacology*
  • Models, Biological
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Polyglutamic Acid / metabolism
  • Structure-Activity Relationship
  • Tetrahydrofolates / metabolism

Substances

  • Anions
  • Carrier Proteins
  • Folic Acid Antagonists
  • Membrane Proteins
  • Tetrahydrofolates
  • Polyglutamic Acid
  • Leucovorin
  • 7-hydroxymethotrexate
  • Methotrexate