The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter

N K Spurr; A C Gough; K Stevenson; C R Wolf

doi:10.1007/BF00293896

The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter

Hum Genet. 1989 Jan;81(2):171-4. doi: 10.1007/BF00293896.

Authors

N K Spurr¹, A C Gough, K Stevenson, C R Wolf

Affiliation

¹ Human Genetic Resources, Imperial Cancer Research Fund, Clare Hall Laboratories, Herts, UK.

PMID: 2563251
DOI: 10.1007/BF00293896

Abstract

The cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and chemicals. Using a full length cDNA clone for the human nifedipine oxidase gene (CYP3) and a panel of human-rodent somatic cell hybrids, we have assigned this gene family to chromosome 7q22-qter. A search for RFLPs using this probe yielded no results.

MeSH terms

Animals
Chromosome Mapping*
Chromosomes, Human, Pair 7*
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System / genetics*
DNA / genetics
DNA Probes
Humans
Hybrid Cells
Mice
Mixed Function Oxygenases / genetics*
Multigene Family*
Nucleic Acid Hybridization
Polymorphism, Restriction Fragment Length

Substances

DNA Probes
DNA
Cytochrome P-450 Enzyme System
Mixed Function Oxygenases
CYP3A protein, human
Cytochrome P-450 CYP3A