Human placental xenobiotic and steroid biotransformations catalyzed by cytochrome P450, epoxide hydrolase, and glutathione S-transferase activities and their relationships to maternal cigarette smoking

Drug Metab Rev. 1989;21(3):427-61. doi: 10.3109/03602538909030305.

Authors

M Pasanen¹, O Pelkonen

Affiliation

¹ Department of Pharmacology and Toxicology, University of Oulu, Finland.

PMID: 2701171
DOI: 10.3109/03602538909030305

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biotransformation
Catalysis
Cytochrome P-450 Enzyme System / metabolism
Epoxide Hydrolases / metabolism
Female
Glutathione Transferase / metabolism
Humans
Maternal-Fetal Exchange
Placenta / enzymology
Placenta / metabolism*
Pregnancy
Smoking / metabolism*
Steroids / metabolism
Steroids / pharmacokinetics*
Xenobiotics / pharmacokinetics*

Substances

Steroids
Xenobiotics
Cytochrome P-450 Enzyme System
Glutathione Transferase
Epoxide Hydrolases