Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine

C Chouza; A Scaramelli; J L Caamaño; O De Medina; R Aljanati; S Romero

doi:10.1016/s0140-6736(86)91223-7

Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine

Lancet. 1986 Jun 7;1(8493):1303-4. doi: 10.1016/s0140-6736(86)91223-7.

Authors

C Chouza, A Scaramelli, J L Caamaño, O De Medina, R Aljanati, S Romero

PMID: 2872433
DOI: 10.1016/s0140-6736(86)91223-7

Abstract

12 subjects, 8 women and 4 men, presented with extrapyramidal motor signs and psychic depression after treatment with flunarizine for between 3 weeks and 15 months. One woman presented with severe symptoms and 20 months after stopping flunarizine she still had dyskinesia and akathisia. The other patients showed partial or complete improvement after withdrawal of the drug.

MeSH terms

Aged
Akathisia, Drug-Induced*
Cinnarizine / adverse effects
Cinnarizine / analogs & derivatives*
Depressive Disorder / chemically induced
Dyskinesia, Drug-Induced / etiology*
Female
Flunarizine
Humans
Male
Middle Aged
Parkinson Disease, Secondary / chemically induced*
Psychoses, Substance-Induced / etiology

Substances

Cinnarizine
Flunarizine