Abstract
The African tree Combretum caffrum (Combretacae) has been found to contain a powerful inhibitor of tubulin polymerization (IC50 2-3 microM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50 approximately 0.003 microM and human colon cancer cell lines [(e.g. LoVo (ED50 = 0.005 microgram/ml), HT 29 (ED50 0.02 microgram/ml, Colo 205 (ED50 = 0.07 microgram/ml), DLD-1 (ED50 = 0.005 microgram/ml) and HCT-15 (ED50 = 0.0009 microgram/ml] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic
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Bibenzyls / chemical synthesis
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Bibenzyls / isolation & purification*
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Bibenzyls / therapeutic use
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Colonic Neoplasms / drug therapy
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Humans
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Leukemia L1210 / drug therapy
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Molecular Structure
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Plant Extracts
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Stilbenes*
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Tubulin Modulators*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Bibenzyls
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Plant Extracts
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Stilbenes
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Tubulin Modulators
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fosbretabulin