Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid

Chem Res Toxicol. 1988 Jul-Aug;1(4):195-9. doi: 10.1021/tx00004a001.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biotransformation
  • Cytochrome P-450 Enzyme System / metabolism
  • Fatty Acids, Monounsaturated / metabolism*
  • Fatty Acids, Monounsaturated / toxicity
  • Liver / drug effects
  • Liver / pathology*
  • Microsomes, Liver / metabolism
  • Valproic Acid / metabolism*
  • Valproic Acid / toxicity

Substances

  • Fatty Acids, Monounsaturated
  • 2-propyl-4-pentenoic acid
  • Valproic Acid
  • Cytochrome P-450 Enzyme System