Clinical pharmacokinetics of doxycycline and minocycline

Clin Pharmacokinet. 1988 Dec;15(6):355-66. doi: 10.2165/00003088-198815060-00001.

Abstract

Doxycycline and minocycline are second-generation tetracyclines. They are readily absorbed, distributed throughout the organism as a function of their lipophilicity and eliminated in both the urine and the faeces. The influence of age, renal disease, malnutrition and hyperlipidaemia is reviewed, together with the main pharmacokinetic interactions.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Doxycycline / metabolism
  • Doxycycline / pharmacokinetics*
  • Drug Interactions
  • Female
  • Humans
  • Kidney Failure, Chronic / metabolism
  • Male
  • Minocycline / metabolism
  • Minocycline / pharmacokinetics*
  • Pregnancy
  • Sex Factors
  • Tetracyclines / pharmacokinetics*
  • Tissue Distribution

Substances

  • Tetracyclines
  • Minocycline
  • Doxycycline