N1-glucosides as urinary metabolites of sulphadimidine, sulphamerazine and sulphamethoxazole

Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):177-83. doi: 10.1007/BF03189937.

Abstract

The synthesis and characterisation of the N1-beta-D-glucosides of the three title sulphonamides are described, and these conjugates are shown, by means of HPLC and MS, to be minor urinary metabolites of these drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Glucosides / urine*
  • Glycosides / urine*
  • Humans
  • Mass Spectrometry
  • Sulfamerazine / urine*
  • Sulfamethazine / urine*
  • Sulfamethoxazole / urine*

Substances

  • Glucosides
  • Glycosides
  • Sulfamethazine
  • Sulfamethoxazole
  • Sulfamerazine