Abstract
A number of agents that mimic the ability of the thyroid hormone, T3, to decrease plasma cholesterol levels are described; one is as effective as T3 at reducing cholesterol levels and stimulating liver function, but has very little effect on cardiac function and is thus less likely to be toxic. The agent may be useful in the treatment of atherosclerosis.
MeSH terms
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Animals
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Binding, Competitive
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Cell Nucleus / metabolism
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Cholesterol / blood*
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Heart / drug effects
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Heart / physiology*
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Hypothyroidism / blood
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Kinetics
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Liver / metabolism
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Myocardium / metabolism
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Rats
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Receptors, Thyroid Hormone* / drug effects
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Receptors, Thyroid Hormone* / metabolism
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Structure-Activity Relationship
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Thyronines / metabolism
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Thyronines / pharmacology*
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Triiodothyronine / metabolism
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Triiodothyronine / pharmacology*
Substances
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Receptors, Thyroid Hormone
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SK&F 94901
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Thyronines
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Triiodothyronine
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Cholesterol