Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test

Mutat Res. 1979 Nov;68(3):211-6. doi: 10.1016/0165-1218(79)90152-6.

Abstract

The mutagenicities of 7 pyrrolizidine alkaloids to Salmonella typhimurium TA100 were demonstrated by a modified Ames's method. The pyrrolizidine alkaloids found to be mutagenic were clivorine, fukinotoxin, heliotrine, lasiocarpine, ligularidine, LX201 and senkirkine. Pre-incubation of these alkaloids with S9 mix and bacteria in a liquid medium was essential for demonstration of their mutagenicities.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cricetinae
  • Dose-Response Relationship, Drug
  • Liver / metabolism
  • Microsomes, Liver / metabolism*
  • Mutation / drug effects*
  • Pyrrolidines / metabolism
  • Pyrrolizidine Alkaloids / pharmacology*
  • Rats
  • Salmonella typhimurium / drug effects*
  • Structure-Activity Relationship

Substances

  • Pyrrolidines
  • Pyrrolizidine Alkaloids