Effect of dietary seaweed preparations on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats

Cancer Lett. 1985 Apr;26(3):241-51. doi: 10.1016/0304-3835(85)90047-3.

Abstract

Nineteen preparations from 8 species of edible seaweeds, sodium alginate and cellulose powder were incorporated into a basic diet in proportions ranging from 0.05% to 2.0%, and used as experimental diets. Experimental rats were fed these diets and controls were fed the basic diet for 12 weeks. All rats also received the carcinogen, 1,2-dimethylhydrazine, during above period. After 20 weeks, all rats were autopsied and the incidence of intestinal tumors induced were examined. There was a significant decrease in incidence in rats fed 6 preparations from Eisenia bicyclis, Laminaria angustata, L. angustata var. longissima and Porphyra tenera (P less than 0.05).

MeSH terms

  • 1,2-Dimethylhydrazine
  • Animals
  • Carcinogens
  • Carrageenan / pharmacology
  • Diet
  • Dimethylhydrazines
  • Intestinal Neoplasms / chemically induced
  • Intestinal Neoplasms / prevention & control*
  • Laminaria
  • Male
  • Rats
  • Rats, Inbred Strains
  • Seaweed* / analysis
  • Sulfuric Acids / analysis

Substances

  • Carcinogens
  • Dimethylhydrazines
  • Sulfuric Acids
  • Carrageenan
  • 1,2-Dimethylhydrazine