Abstract
Simultaneous administration of monensin and tiamulin to pigs resulted in enhanced myotoxicity. Skeletal muscles of tongue, diaphragm and legs were preferentially affected, whereas the masseter, longissimus thoracis and cardiac muscles, including the left auricle, were spared. Histochemical examination revealed an involvement of both type I and II fibers of skeletal muscles.
MeSH terms
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Animals
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Anti-Bacterial Agents / toxicity*
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Diterpenes / toxicity
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Drug Synergism
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Food Additives
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Furans / toxicity*
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Histocytochemistry
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Male
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Monensin / toxicity*
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Muscles / pathology
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Muscular Diseases / chemically induced
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Muscular Diseases / pathology
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Muscular Diseases / veterinary*
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Swine
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Swine Diseases / chemically induced*
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Swine Diseases / pathology
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Weaning
Substances
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Anti-Bacterial Agents
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Diterpenes
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Food Additives
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Furans
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Monensin
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tiamulin