Lack of congruence of S-carboxymethyl-L-cysteine sulphoxidation and debrisoquine 4-hydroxylation in a Caucasian population

Xenobiotica. 1985 May;15(5):445-50. doi: 10.3109/00498258509045015.

Abstract

One-hundred-and-twenty volunteers and three families were investigated for possible association between the sulphoxidation of S-carboxymethyl-L-cysteine and the debrisoquine hydroxylation polymorphism. The observed individual variations in these two metabolic reactions were shown not to be concordant (rs = 0.068) and any heritable factors controlling the major aspects of these phenomena do not co-segregate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Carbocysteine / metabolism*
  • Cysteine / analogs & derivatives*
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism
  • Debrisoquin / metabolism*
  • Female
  • Humans
  • Hydroxylation
  • Isoquinolines / metabolism*
  • Male
  • Middle Aged
  • Mixed Function Oxygenases / genetics*
  • Mixed Function Oxygenases / metabolism
  • Oxidation-Reduction
  • Polymorphism, Genetic
  • Sulfoxides / biosynthesis
  • White People

Substances

  • Isoquinolines
  • Sulfoxides
  • Carbocysteine
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Cytochrome P-450 CYP2D6
  • Cysteine
  • Debrisoquin