Abstract
One-hundred-and-twenty volunteers and three families were investigated for possible association between the sulphoxidation of S-carboxymethyl-L-cysteine and the debrisoquine hydroxylation polymorphism. The observed individual variations in these two metabolic reactions were shown not to be concordant (rs = 0.068) and any heritable factors controlling the major aspects of these phenomena do not co-segregate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Carbocysteine / metabolism*
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Cysteine / analogs & derivatives*
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Cytochrome P-450 CYP2D6
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Cytochrome P-450 Enzyme System / genetics
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Cytochrome P-450 Enzyme System / metabolism
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Debrisoquin / metabolism*
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Female
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Humans
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Hydroxylation
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Isoquinolines / metabolism*
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Male
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Middle Aged
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Mixed Function Oxygenases / genetics*
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Mixed Function Oxygenases / metabolism
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Oxidation-Reduction
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Polymorphism, Genetic
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Sulfoxides / biosynthesis
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White People
Substances
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Isoquinolines
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Sulfoxides
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Carbocysteine
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Cytochrome P-450 Enzyme System
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Mixed Function Oxygenases
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Cytochrome P-450 CYP2D6
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Cysteine
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Debrisoquin