Halothane hepatotoxicity: relation between metabolic activation, hypoxia, covalent binding, lipid peroxidation and liver cell damage

Hepatology. 1983 Jul-Aug;3(4):601-6. doi: 10.1002/hep.1840030421.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cytochrome P-450 Enzyme System / metabolism
  • Halothane / metabolism
  • Halothane / toxicity*
  • Humans
  • Hypoxia / metabolism*
  • Lipid Peroxides / metabolism*
  • Liver / drug effects*
  • Liver / metabolism
  • Microsomes, Liver / metabolism
  • Oxidation-Reduction
  • Rats

Substances

  • Lipid Peroxides
  • Cytochrome P-450 Enzyme System
  • Halothane