Abstract
Genotoxicity of emodin was studied in the Salmonella/microsome assay, the sister-chromatid exchange (SCE) assay and the hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) forward mutation assay with V79 Chinese hamster cells. In the Salmonella/microsome assay, emodin was found to be positive in TA97, TA100 and TA1537 in the presence of liver homogenate. In TA1537 a weak direct mutagenicity was also observed. In both mammalian test systems, no genotoxicity was found either with or without metabolic activation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthraquinones / toxicity*
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Biotransformation
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Cell Line
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Cricetinae
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Cricetulus
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Emodin / metabolism
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Emodin / pharmacology
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Emodin / toxicity*
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Hypoxanthine Phosphoribosyltransferase / genetics*
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Lung
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Male
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Microsomes, Liver / metabolism
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Mutagenicity Tests
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Mutagens*
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Mutation*
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Rats
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Rats, Inbred Strains
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Salmonella typhimurium / drug effects
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Sister Chromatid Exchange / drug effects*
Substances
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Anthraquinones
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Mutagens
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Hypoxanthine Phosphoribosyltransferase
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Emodin