Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): relationship to inhibition of brain adenosine deaminase

Psychopharmacology (Berl). 1983;79(2-3):126-9. doi: 10.1007/BF00427798.

Abstract

Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Adenosine Deaminase Inhibitors*
  • Animals
  • Brain / enzymology*
  • Brain Chemistry / drug effects
  • Electroencephalography*
  • Hypnotics and Sedatives*
  • Male
  • Motor Activity / drug effects
  • Nucleoside Deaminases / antagonists & inhibitors*
  • Rats
  • Rats, Inbred Strains

Substances

  • Adenosine Deaminase Inhibitors
  • Hypnotics and Sedatives
  • 9-(2-hydroxy-3-nonyl)adenine
  • Nucleoside Deaminases
  • Adenine