Localization of metabolic activation and deactivation systems in the lung: significance to the pulmonary toxicity of xenobiotics

Annu Rev Pharmacol Toxicol. 1983:23:217-38. doi: 10.1146/annurev.pa.23.040183.001245.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Ascorbic Acid / metabolism
  • Biotransformation
  • Cytochrome P-450 Enzyme System / metabolism*
  • Glutathione / metabolism*
  • Humans
  • Isoenzymes / metabolism*
  • Lung / drug effects
  • Lung / enzymology
  • Lung / metabolism*
  • NADP / metabolism
  • NADPH-Ferrihemoprotein Reductase / metabolism*
  • Oxygen / metabolism*
  • Oxygenases / metabolism*
  • Peroxides / metabolism
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Xanthine Oxidase / metabolism

Substances

  • Isoenzymes
  • Peroxides
  • NADP
  • Cytochrome P-450 Enzyme System
  • Oxygenases
  • Prostaglandin-Endoperoxide Synthases
  • Xanthine Oxidase
  • NADPH-Ferrihemoprotein Reductase
  • Glutathione
  • Ascorbic Acid
  • Oxygen