Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism of the beta-carbolines harmine and harmol

Biochem Pharmacol. 1983 Feb 15;32(4):653-63. doi: 10.1016/0006-2952(83)90490-2.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Alkaloids / metabolism*
  • Animals
  • Carbolines / metabolism*
  • Cytochrome P-450 Enzyme System / metabolism
  • Dealkylation
  • Enzyme Induction / drug effects
  • Harmine / analogs & derivatives
  • Harmine / metabolism*
  • Indoles / metabolism*
  • Kinetics
  • Male
  • Methylcholanthrene / pharmacology*
  • Mice
  • Mice, Inbred C57BL
  • Microsomes, Liver / metabolism*
  • Phenobarbital / pharmacology*

Substances

  • Alkaloids
  • Carbolines
  • Indoles
  • harmol
  • Harmine
  • Methylcholanthrene
  • Cytochrome P-450 Enzyme System
  • Phenobarbital