Potentiation of acrylate ester toxicity by prior treatment with the carboxylesterase inhibitor triorthotolyl phosphate (TOTP)

Toxicol Appl Pharmacol. 1981 Feb;57(2):208-19. doi: 10.1016/0041-008x(81)90281-7.
No abstract available

MeSH terms

  • Acrylates / metabolism
  • Acrylates / toxicity*
  • Animals
  • Carboxylic Ester Hydrolases / antagonists & inhibitors*
  • Cresols / pharmacology*
  • Drug Synergism
  • Hydrolysis
  • Male
  • Proteins / metabolism
  • Rats
  • Sulfhydryl Compounds / metabolism
  • Tritolyl Phosphates / pharmacology*

Substances

  • Acrylates
  • Cresols
  • Proteins
  • Sulfhydryl Compounds
  • Tritolyl Phosphates
  • Carboxylic Ester Hydrolases
  • tri-o-cresyl phosphate