Abstract
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Blood Coagulation / drug effects
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Chemical Phenomena
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Chemistry
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Cytochrome P-450 Enzyme System / metabolism
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Enzyme Induction / drug effects
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In Vitro Techniques
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Microsomes, Liver / metabolism
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Mutagens
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Rats
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Salmonella / drug effects
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Salmonella / genetics
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Stereoisomerism
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Vitamin K 1 / antagonists & inhibitors
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Warfarin / chemical synthesis
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Warfarin / metabolism*
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Warfarin / pharmacology
Substances
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Mutagens
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Warfarin
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Vitamin K 1
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Cytochrome P-450 Enzyme System