Abstract
The rat brain capillary permeability coefficient was determined for 27 compounds. The relationship of permeability to octanol/water partition coefficient and molecular weight was found to be predictable for drugs with molecular weights less than 400.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Blood-Brain Barrier*
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Brain / blood supply
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Capillary Permeability
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Male
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Models, Biological
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Molecular Weight*
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Rats
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Rats, Inbred F344
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Solubility*
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Structure-Activity Relationship