Abstract
Twenty-three healthy, male volunteers completed this doubleblind, randomized, placebo controlled, 2-period crossover study to assess the influence of multiple doses of pantoprazole on single-dose phenytoin pharmacokinetics. During each treatment period, the volunteers received either one 40 mg pantoprazole tablet or placebo for 7 days. In addition, a single-dose of 300 mg (3 x 100 mg capsules) phenytoin sodium was administered on day 4 of each treatment period. A 14-day wash-out period was allowed between phenytoin administrations. The results indicate that pantoprazole neither affects the rate nor the extent of absorption, nor the elimination of phenytoin.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles
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Absorption / drug effects
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Administration, Oral
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Adolescent
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Adult
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Benzimidazoles / administration & dosage
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Benzimidazoles / pharmacology*
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Biological Availability
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Chromatography, High Pressure Liquid
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Cross-Over Studies
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Double-Blind Method
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Drug Interactions
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Humans
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Male
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Omeprazole / analogs & derivatives
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Pantoprazole
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Phenytoin / administration & dosage
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Phenytoin / blood
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Phenytoin / pharmacokinetics*
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Proton Pump Inhibitors*
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Reference Standards
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Sulfoxides / administration & dosage
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Sulfoxides / pharmacology*
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White People
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Benzimidazoles
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Proton Pump Inhibitors
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Sulfoxides
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Phenytoin
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Pantoprazole
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Omeprazole