Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis

C R Pace-Asciak; D Reynaud; P M Demin

doi:10.1007/BF02538262

Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis

Lipids. 1995 Feb;30(2):107-14. doi: 10.1007/BF02538262.

Authors

C R Pace-Asciak¹, D Reynaud, P M Demin

Affiliation

¹ Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

PMID: 7769965
DOI: 10.1007/BF02538262

Abstract

This article reviews published evidence describing the enzymatic and nonenzymatic formation and the routes of metabolism of the hepoxilins. Also treated are the major approaches used for the chemical synthesis of these compounds and for some of their analogs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

8,11,14-Eicosatrienoic Acid / analogs & derivatives
8,11,14-Eicosatrienoic Acid / chemical synthesis
8,11,14-Eicosatrienoic Acid / metabolism
Animals
Drug Stability
Leukotrienes / chemical synthesis
Leukotrienes / metabolism*
Molecular Structure

Substances

Leukotrienes
12-HPETE
10-hydroxy-11,12-epoxyeicosa-5,8,14-trienoic acid
8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid
8,11,14-Eicosatrienoic Acid