Abstract
Fungal infections are increasingly common and, in certain vulnerable patients, can be serious and even life threatening. The fungal cell wall, a structure with no mammalian counterpart, presents an attractive therapeutic target. Inhibitors of the synthesis of one cell-wall component, beta-(1,3)-glucan, are currently under development as antifungal and antipneumocystis agents.
MeSH terms
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Antifungal Agents / pharmacology*
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Carbohydrate Sequence
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Cell Wall / drug effects*
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Chitin / biosynthesis
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Chitin Synthase / antagonists & inhibitors*
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Glucans / biosynthesis
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Glucosyltransferases / antagonists & inhibitors*
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Molecular Sequence Data
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Mycoses / drug therapy*
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beta-Glucans*
Substances
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Antifungal Agents
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Glucans
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beta-Glucans
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Chitin
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beta-1,3-glucan
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Glucosyltransferases
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glucan synthase
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Chitin Synthase