In vitro but not in vivo inhibition of CYP2D6 by phenethyl isothiocyanate (PEITC), a constituent of watercress

Pharmacogenetics. 1994 Oct;4(5):275-80. doi: 10.1097/00008571-199410000-00006.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anticarcinogenic Agents / pharmacology*
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 Enzyme Inhibitors*
  • Debrisoquin / metabolism
  • Female
  • Humans
  • Isothiocyanates / pharmacology*
  • Male
  • Microsomes, Liver / enzymology
  • Microsomes, Liver / metabolism
  • Mixed Function Oxygenases / antagonists & inhibitors*
  • Plants / chemistry*

Substances

  • Anticarcinogenic Agents
  • Cytochrome P-450 Enzyme Inhibitors
  • Isothiocyanates
  • phenethyl isothiocyanate
  • Mixed Function Oxygenases
  • Cytochrome P-450 CYP2D6
  • Debrisoquin