Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

Pharmacogenetics. 1994 Feb;4(1):39-42. doi: 10.1097/00008571-199402000-00005.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Aryl Hydrocarbon Hydroxylases*
  • Cytochrome P-450 CYP2C9
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Humans
  • Recombinant Proteins / metabolism
  • Stereoisomerism
  • Steroid 16-alpha-Hydroxylase*
  • Tolbutamide / analogs & derivatives
  • Tolbutamide / analysis
  • Tolbutamide / metabolism
  • Tumor Cells, Cultured
  • Warfarin / analogs & derivatives
  • Warfarin / analysis
  • Warfarin / metabolism*

Substances

  • Recombinant Proteins
  • hydroxymethyltolbutamide
  • Warfarin
  • Cytochrome P-450 Enzyme System
  • Tolbutamide
  • 7-hydroxywarfarin
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • Steroid 16-alpha-Hydroxylase
  • 6-hydroxywarfarin