Abstract
Magnolol and honokiol, biphenyl compounds, were isolated as anti-emetic principles from the methanolic extract of Magnolia obovata bark. [6]-, [8]-, and [10]-shogaols and [6]-, [8]-, and [10]-gingerols were isolated from the methanolic extract of Zingiber officinale rhizome as anti-emetic principles. Some phenyl-propanoids with allyl side-chains were found to show the same activity. They inhibited the emetic action induced by the oral administration of copper sulfate pentahydrate to leopard and ranid frogs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiemetics / isolation & purification
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Antiemetics / pharmacology*
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Anura
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Biphenyl Compounds / isolation & purification
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Biphenyl Compounds / pharmacology
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Catechols / isolation & purification
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Catechols / pharmacology
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Fatty Alcohols / isolation & purification
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Fatty Alcohols / pharmacology
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Female
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Lignans*
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Male
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Plants, Medicinal / chemistry*
Substances
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Antiemetics
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Biphenyl Compounds
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Catechols
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Fatty Alcohols
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Lignans
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magnolol
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honokiol
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shogaol
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gingerol