Abstract
Using a modified FCA (Freund's complete adjuvant) procedure, the sensitizing capacity of Euxyl K 400 and its ingredients, 1,2-dibromo-2,4-dicyanobutane and 2-phenoxyethanol, has been studied in guinea pigs. The experiments demonstrate that a distinct but weak sensitizing potency exists for Euxyl K 400 and dibromodicyanobutane. Phenoxyethanol remained almost negative. These results are in good accordance with the low number of cases of allergic contact dermatitis due to Euxyl K 400 and dibromodicyanobutane described since their introduction on the market. Cases of phenoxyethanol contact allergy have been published hitherto only 4x in the medical literature.
MeSH terms
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Allergens / adverse effects
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Allergens / analysis
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Allergens / immunology
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Animals
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Anti-Infective Agents, Local / adverse effects
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Anti-Infective Agents, Local / analysis
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Anti-Infective Agents, Local / immunology
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Dermatitis, Irritant / immunology*
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Ethylene Glycols / adverse effects
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Ethylene Glycols / analysis
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Ethylene Glycols / chemistry
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Ethylene Glycols / immunology*
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Guinea Pigs
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Nitriles / adverse effects
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Nitriles / analysis
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Nitriles / chemistry
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Nitriles / immunology*
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Preservatives, Pharmaceutical / adverse effects*
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Preservatives, Pharmaceutical / chemistry
Substances
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Allergens
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Anti-Infective Agents, Local
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Ethylene Glycols
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Nitriles
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Preservatives, Pharmaceutical
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phenoxyethanol
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1,2-dibromo-2,4-dicyanobutane