Demonstration of the myocardial salvage effect of lithospermic acid B isolated from the aqueous extract of Salvia miltiorrhiza

K P Fung; L H Zeng; J Wu; H N Wong; C M Lee; P M Hon; H M Chang; T W Wu

doi:10.1016/0024-3205(93)90471-e

Demonstration of the myocardial salvage effect of lithospermic acid B isolated from the aqueous extract of Salvia miltiorrhiza

Life Sci. 1993;52(22):PL239-44. doi: 10.1016/0024-3205(93)90471-e.

Authors

K P Fung¹, L H Zeng, J Wu, H N Wong, C M Lee, P M Hon, H M Chang, T W Wu

Affiliation

¹ Department of Clinical Biochemistry, University of Toronto, Ont., Canada.

PMID: 8492636
DOI: 10.1016/0024-3205(93)90471-e

Abstract

Lithospermic acid B has been isolated to > 95% purity by high performance liquid chromatography from the aqueous extract of the roots of Salvia miltiorrhiza. When infused at 5.5 mumoles/kg into the post-ischemic rabbit heart, it reduced by 62 +/- 10% (n = 8) the myocardial damage found in the saline control in a rabbit ischemia-reperfusion model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal / isolation & purification
Drugs, Chinese Herbal / therapeutic use*
Male
Microscopy, Electron
Myocardial Ischemia / drug therapy*
Myocardial Reperfusion
Myocardium / ultrastructure
Rabbits

Substances

Drugs, Chinese Herbal
lithospermate B