Abstract
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antibiotics, Antineoplastic / chemistry*
-
Antineoplastic Agents / chemistry*
-
Humans
-
Lung Neoplasms / drug therapy
-
Mice
-
Mice, Nude
-
Neoplasm Transplantation
-
Polycyclic Sesquiterpenes
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / therapeutic use
-
Spiro Compounds / chemistry
-
Spiro Compounds / therapeutic use
Substances
-
Antibiotics, Antineoplastic
-
Antineoplastic Agents
-
Polycyclic Sesquiterpenes
-
Sesquiterpenes
-
Spiro Compounds
-
acylfulvene
-
illudin S