Hepatic drug-metabolizing activities in rats after 14 days of oral administration of the human immunodeficiency virus-type 1 protease inhibitor ritonavir (ABT-538)

Drug Metab Dispos. 1996 May;24(5):615-7.

Authors

G N Kumar¹, B Grabowski, R Lee, J F Denissen

Affiliation

¹ Department of Biotransformation, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.

PMID: 8723745

No abstract available

MeSH terms

Animals
Cytochrome P-450 Enzyme System / metabolism*
Enzyme Induction
Ethinyl Estradiol / metabolism
Female
Glucuronosyltransferase / biosynthesis*
HIV Protease Inhibitors / pharmacology*
Male
Microsomes, Liver / enzymology
Microsomes, Liver / metabolism*
Organ Size
Rats
Rats, Sprague-Dawley
Ritonavir / pharmacology*

Substances

HIV Protease Inhibitors
Ethinyl Estradiol
Cytochrome P-450 Enzyme System
Glucuronosyltransferase
Ritonavir