Abstract
Four coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified as 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7-methoxycoumarin (scopoletin) (4). This is the first report of the isolation of aesculetin and scopolin from the genus Santolina. The isolated coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Calcimycin / pharmacology
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Carrageenan
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Chromatography, Thin Layer
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Dinoprostone / metabolism
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Inflammation / chemically induced
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Inflammation / prevention & control
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Ionophores / pharmacology
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Leukotrienes / metabolism
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / metabolism
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Magnetic Resonance Spectroscopy
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Mice
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plants, Medicinal / chemistry*
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Rats
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Rats, Wistar
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Spain
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Spectrophotometry, Ultraviolet
Substances
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Anti-Inflammatory Agents
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Coumarins
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Ionophores
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Leukotrienes
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Plant Extracts
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Calcimycin
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Carrageenan
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Dinoprostone