Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol

Adv Exp Med Biol. 1997:414:133-46. doi: 10.1007/978-1-4615-5871-2_16.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma
  • Aldehyde Dehydrogenase / antagonists & inhibitors*
  • Aldehyde Dehydrogenase / biosynthesis
  • Antineoplastic Agents, Alkylating / toxicity*
  • Breast Neoplasms
  • Catechols / pharmacology
  • Cell Survival / drug effects*
  • Cyclophosphamide / analogs & derivatives*
  • Cyclophosphamide / toxicity
  • Enzyme Induction
  • Female
  • Gastric Mucosa / enzymology
  • Gossypol / toxicity*
  • Humans
  • Kinetics
  • Phosphoramide Mustards / toxicity*
  • Recombinant Proteins / antagonists & inhibitors
  • Recombinant Proteins / biosynthesis
  • Substrate Specificity
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Alkylating
  • Catechols
  • Phosphoramide Mustards
  • Recombinant Proteins
  • corneal protein 54, bovine
  • phosphoramide mustard
  • mafosfamide
  • Cyclophosphamide
  • Aldehyde Dehydrogenase
  • Gossypol
  • catechol