Abstract
Cyclophosphamide 100 mg/kg i.p. increased the duration of ketamine-induced anesthesia in BALB/c mice by 39%. However, combined action of these two substances did not change the number of splenocytes, proliferation of T cells, or phagocytic activity of murine peritoneal macrophages against Candida albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anesthesia
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Anesthetics, Dissociative / pharmacology*
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Animals
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Cyclophosphamide / pharmacology*
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Drug Interactions
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Drug Synergism
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Drug Therapy, Combination
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Immunosuppressive Agents / pharmacology*
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Ketamine / pharmacology*
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Male
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Mice
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Mice, Inbred BALB C
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Spleen / cytology
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Spleen / drug effects
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T-Lymphocytes / drug effects
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T-Lymphocytes / metabolism
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Time Factors
Substances
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Anesthetics, Dissociative
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Immunosuppressive Agents
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Ketamine
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Cyclophosphamide